Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly.

Schaan Profes M, Tiroumalechetty A, Patel N, Lauar SS, Sidoli S, Kurshan PT.

PLoS Biol. 2024 January 22;22(1): e3002466.
doi: 10.1371/journal.pbio.3002466. 


Protein-lipid interactions drive presynaptic assembly upstream of cell adhesion molecules.

Frankel EB, Tiroumalechetty A, Henry PS, Su Z, Wu Y, Kurshan PT.

bioRxiv 2023 November 17.
doi: 10.1101/2023.11.17.567618.


C. elegans Clarinet/CLA-1 recruits RIMB-1/RIM-binding protein and UNC-13 to orchestrate presynaptic neurotransmitter release.

Krout M, Oh KH, Xiong A, Frankel EB, Kurshan PT, Kim H, Richmond JE.

Proc Natl Acad Sci U S A 2023 May 23;120(21)::e2220856120.
doi: 10.1073/pnas.2220856120.


All Talk, No Assembly: Voltage-Gated Calcium Channels Do Not Mediate Active Zone Formation.

Frankel EB, Kurshan PT.

Neuron 2020 Aug 19;107(4):593-594.
doi: 10.1016/j.neuron.2020.07.028.


Synaptogenic pathways.

Kurshan PT, Shen K.

Curr Opin Neurobiol. 2019 Apr 12;57:156-162. doi: 10.1016/j.conb.2019.03.005. Review.


γ-Neurexin and Frizzled Mediate Parallel Synapse Assembly Pathways Antagonized by Receptor Endocytosis.

Kurshan PT, Merrill SA, Dong Y, Ding C, Hammarlund M, Bai J, Jorgensen EM, Shen K.

Neuron. 2018 Oct 10;100(1):150-166.e4. doi: 10.1016/j.neuron.2018.09.007.


Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release.

Xuan Z, Manning L, Nelson J, Richmond JE, Colón-Ramos DA, Shen K, Kurshan PT.

Elife. 2017 Nov 21;6. pii: e29276. doi: 10.7554/eLife.29276. Free PMC Article


Deep phenotyping unveils hidden traits and genetic relations in subtle mutants.

San-Miguel A, Kurshan PT, Crane MM, Zhao Y, McGrath PT, Shen K, Lu H.

Nat Commun. 2016 Nov 23;7:12990. doi: 10.1038/ncomms12990. Free PMC Article

Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species.

He J, Zhou R, Wu Z, Carrasco MA, Kurshan PT, Farley JE, Simon DJ, Wang G, Han B, Hao J, Heller E, Freeman MR, Shen K, Maniatis T, Tessier-Lavigne M, Zhuang X.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6029-34. doi: 10.1073/pnas.1605707113. Epub 2016 May 9. Free PMC Article


Regulation of synaptic extracellular matrix composition is critical for proper synapse morphology.

Kurshan PT, Phan AQ, Wang GJ, Crane MM, Lu H, Shen K.

J Neurosci. 2014 Sep 17;34(38):12678-89. doi: 10.1523/jneurosci.1183-14.2014. Free PMC Article


Autonomous screening of C. elegans identifies genes implicated in synaptogenesis.

Crane MM, Stirman JN, Ou CY, Kurshan PT, Rehg JM, Shen K, Lu H.

Nat Methods. 2012 Oct;9(10):977-80. doi: 10.1038/nmeth.2141. Free PMC Article

Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions.

Kurshan PT, Oztan A, Schwarz TL.

Nat Neurosci. 2009 Nov;12(11):1415-23. doi: 10.1038/nn.2417. Free PMC Article


Mutations in a Drosophila alpha2delta voltage-gated calcium channel subunit reveal a crucial synaptic function.

Dickman DK*, Kurshan PT*, Schwarz TL.

J Neurosci. 2008 Jan 2;28(1):31-8. doi: 10.1523/jneurosci.4498-07.2008. Free Article


A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport.

Pack-Chung E, Kurshan PT, Dickman DK, Schwarz TL.

Nat Neurosci. 2007 Aug;10(8):980-9.

For a full list of publications see PubMed profile